Isolation and Identification of Geraniol Compounds from the Essential Oil of Cymbopogon nardus (L.) Rendle

  • Yelfi Anwar Universitas 17 Agustus 1945 Jakarta
  • Shirly Kumala Fakultas Farmasi Universitas Pancasila
  • Elvina Dhiaul Iftitah Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Brawijaya
  • Partomuan Simanjuntak Fakultas Farmasi Universitas Pancasila

Abstract

Background: Indonesia is a major producer of several essential oils such as citronella oil, clove oil, cananga oil, vetiver oil, sandalwood oil, and patchouli oil. The Cymbopogon (Poaceae) genus has the most important components of essential oils, namely citral, geraniol, citronellol, citronellal. Geraniol is one of the most important chemical compounds in the aroma and fragrance industry and shows the nature of insecticides and natural insect repellents which show low toxicity and is suggested to represent a new class of chemoprevention agents for cancer, antimicrobial, anti-oxidant, anti-inflammatory and some vascular effects Transdermal drugs also attract the attention of researchers and scientists in the field of formulation.


Objective: This study aimed to obtain geraniol compounds obtained from Cymbopogon nardus (L.) Rendle and identification.


Methodology: The citronella, essential oil was obtained from the Cymbopogon nardus (L) Rendle plant using a water-steam distillation method, then fractionation was carried out and continued by purification isolation by column chromatography.


Results: Based on the interpretation of IR data, Core magnetic resonance (proton and carbon RMI) and mass spectra for isolate 5 were determined as geraniol compounds.


Conclusion: Geraniol can be obtained from Cymbopogon nardus (L) Rendle plants by water-steam distillation, fractionation and isolation methods.

References

1. Anonim. http://www.kemendag.go.id/id/economic-profile/indonesia-export-import/growth-of-non-oil-and-gas-export-commodity. Diakses tanggal 2 Februari 2019

2. Ganjewala D. Cymbopogon essential oils : Chemical compositions and bioactivities. Int J Essent Oil Ther. 2009;3(APRIL 2009):56–65.

3. De Toledo LG, Dos Santos Ramos MA, Spósito L, Castilho EM, Pavan FR, De Oliveira Lopes É, et al. Essential oil of Cymbopogon nardus (L.) Rendle: A strategy to combat fungal infections caused by Candida species. Int J Mol Sci. 2016;17(8).

4. Chen W, Viljoen AM. Geraniol — A review of a commercially important fragrance material. South African J Bot [Internet]. 2010;76(4):643–51. Available from: http://dx.doi.org/10.1016/j.sajb.2010.05.008

5. Chen W, Viljoen AM. Geraniol - A review of a commercially important fragrance material. South African J Bot [Internet]. 2010;76(4):643–51. Available from: http://dx.doi.org/10.1016/j.sajb.2010.05.008

6. Singh BR, Agrawal R, Bhardwaj M, Dubey S. Clinical & Medical Biochemistry : Open Access Antimicrobial Activity of Citronella Essential Oil on Antimicrobial Drug Resistant Bacteria from Veterinary Clinical Cases. 2015;1(1):1–9.

7. Oliveira MMM de, Brugnera DF, Cardoso M das G, Alves E, Piccoli RH. Disinfectant action of Cymbopogon sp. essential oils in different phases of biofilm formation by Listeria monocytogenes on stainless steel surface. Food Control. 2010;21(4):549–53.

8. Warnke PH, Becker ST, Podschun R, Sivananthan S, Springer IN, Russo PAJ, et al. The battle against multi-resistant strains: Renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections. J Cranio-Maxillofacial Surg. 2009;37(7):392–7.

9. Baser, K.H.C. GB. Handbook Of Essential Oils, Science, Technology And Applications. United States Of America: CRC Press, Taylor & Francis Group; 2010.

10. Hamzah MH, Che Man H, Abidin ZZ, Jamaludin H. Comparison of citronella oil extraction methods from Cymbopogon nardus grass by ohmic-heated hydro-distillation, hydro-distillation, and steam distillation. BioResources. 2014;9(1):256–72.

11. Pattusamy V, Nandini N, Vijay M, Bheemappa K. Chemical Analysis and Therapeutic Uses of Citronella Oil from Cymbopogon Winterianus : A Short Review. Int J Adv Res. 2013;1(2320):77–82.

12. Riyanto R, Untari DT, Cahyandaru N. Isolation and Application of the Lemongrass Essential Oil of Cymbopogon Nardus L.as a Growth Inhibitor of Lichens on Stone Cultural Heritage. IOSR J Appl Chem [Internet]. 2016;09(09):109–17. Available from: http://iosrjournals.org/iosr-jac/papers/vol9-issue9/Version-2/S090902109117.pdf

13. Siwi I R, Rusli M S AE. Pemisahan fraksi kaya sitronelal, sitronelol, dan geraniol minyak sereh wangi menggunakan distilasi fraksinasi vakum imastia rahma siwi. Teknol Dep Pertanian, Ind Pertanian, Fak Teknol. 2013;

14. Grice ID, Rogers KL, Griffiths LR. Isolation of bioactive compounds that relate to the anti-platelet activity of Cymbopogon ambiguus. Evidence-based Complement Altern Med. 2011;2011.

15. Chong DJW, Latip JB, Hasbullah SAB, Sastrohamidjojo H. Separation of geraniol from citronellol by selective oxidation of geraniol to geranial. Sains Malaysiana. 2015;44(8):1183–8.

16. Jeon JH, Lee CH, Lee HS. Food Protective Effect of Geraniol and Its Congeners against Stored Food Mites. 2009;72(7):1468–71.
Published
2019-10-29
How to Cite
ANWAR, Yelfi et al. Isolation and Identification of Geraniol Compounds from the Essential Oil of Cymbopogon nardus (L.) Rendle. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 17, n. 2, p. 183-188, oct. 2019. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/746>. Date accessed: 18 nov. 2019. doi: https://doi.org/10.35814/jifi.v17i2.746.
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Articles