Physical Stability of Curcumin Transethosome Using Combinations Tween 60 and Span 60 as Surfactant

  • Yudi Srifiana Fakultas Farmasi dan Sains, Universitas Muhammadiyah Prof. DR HAMKA
  • Anisa Amalia Fakultas Farmasi dan Sains, Universitas Muhammadiyah Prof. DR HAMKA
  • Yusnia Yusnia Fakultas Farmasi dan Sains, Universitas Muhammadiyah Prof. DR HAMKA
DOI: https://doi.org/10.35814/jifi.v18i2.796

Abstract

Curcumin has low solubility in water and has low stability so that a drug delivery system is needed


that can overcome these problems. One delivery system that can be used to overcome these problems is


transethosome. Transethosome is composed of several component, one of them is surfactant. Surfactant is a component that can help improve the stability of the transethosome system so that in this study research was conducted on the eff ect of the use of a combination of surfactants (tween 60 and span 60) on the physical stability of transethosome curcumin. In this study used a combination of tween 60 and span 60 with a ratio of 1: 2, 1: 1, 2: 1 at a concentration of 5%. Transethosome formed then characterized include organoleptic, viscosity, particle size and particle size distribution, zeta potential, adsorption effi ciency and pH. Transethosome characteristics were observed for 8 weeks to see the physical stability of the transethosome. The results at week 0 indicate that the transethosome formed a suspension with orange color and smelled of phosphatidylcholine with the highest viscosity in formula 3, has a particle size of 1-1000 nm, polydispersity 0-0.571, has a negative zeta potential value, has an absorption effi ciency above 80 % and pH 8.5-10.0. Physical stability test results show the use of a combination of tween 60 and span 60 with rasio 3:1 (F3) can improve the physical stability of transethosome curcumin.

References

1. Abdulbaqi MI, Darwis Y, Khan NA, Assi RA and
Arshad A Khan. Ethosomal Nanocarriers : The Impact
of Constituents and Formulation Techniques on
Ethosomal Properties, In Vivo Studies, and Clinical
Trials. Internasional Journal of Medicine. 2016.11.
2279 - 2304.

2. Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav
VR, Tekmal RR and Aggarwal BB. Design of Curcumin-
loaded PLGA Nanoparticles Formulation with
Enhanced Cellular Uptake, and Increased Bioactivity
In Vitro and Superior Bioavailability In Vivo. Biochem
Pharmacol. 2010. 79(3), 330 - 8.

3. Ascenso A, Raposo S, Batista C, Cardoso P, Mendes T,
Praca FG, Bentley MVLB and Sandra Simões. Development,
Characterization, and Skin Delivery Studies
of Related Ultradeformable Vesicles: Transfersomes,
Ethosomes, and Transethosomes. Int J Nanomedicine.
2015. 10, 5837 - 51.

4. Das S and A Chaudhury. Recent Advances in Lipid
Nanoparticle Formulation with Solid Matrix for Oral
Drug Delivery. AAPS PharmSciTech. 2011. 12 (1),
62 – 76.

5. Goeswin A. Sistem Penghantaran Obat Pelepasan
Terkendali, Seri III. Penerbit ITB : Bandung. 2012.
Hal : 257 - 66.

6. Jacob L and KR Anoop. A Review on Surfactant as
Edge Activator in Ultradeformable Vesicel for Enhanced
Skin Delivery. Int J Pharm Bio Sc. 2013. 4
(3), 337 - 44.

7. Joe B, Vijaykumar M and BR Lokesh. Biological
Properties of Curcumin-Cellular and Molecular Mechanisms
of Action. Journal Critical Review in Food
Science and Nutrition. 2010. 44, 97 - 111

8. Kumar L, Verma S, Singh K, Prasad DN and Amir
Kumar Jain. Ethanol Based Vesicular Carriers in
Transdermal Drug Delivery: Nanoethosomes and
Transethosomes in Focus. Nano World Journal. 2016.
2 (3), 41 - 51.

9. Liu W, Zhai Y, Heng X, Che FY, Chen W, Sun D and
Guangxi Zhai. Oral Bioavaibility of Curcumin : Problems
and Advancements. Journal of Drug Targetting.
2016. 24 (8), 694 – 702.

10. Maiti K, Mukherjee K, Gantait A, Saha BP and Pulok
K Mukherjee. Curcumin-phospolipid Complex :
Jurnal Ilmu Kefarmasian 191 SRIFIANA ET AL. Indonesia
Preparation, Therapeutic Evaluation and Pharmacokinetic
Study in Rats. International Journal of Pharmaceutics.
2007. 330 (1 - 2), 155 – 63.

11. Nadhin M, Indumathy R, sreeram KJ and Nair BU.
Synthesis of Iron Oxide Nanoparticles of Narrow Size
Distribution on Polysaccharide Template. Bull Mater
Science. 2008. 31 (1), 93 – 6.

12. Ratnasari D dan Effionora Anwar. Karakterisasi
Nanovesikel Transfersom sebagai Pembawa Rutin
dalam Pengembangan Sediaan Transdermal. Jurnal
Farmamedika. 2016. 1 (1), 1- 7.

13. Rowe RC, Sheskey PJ and Marian E Quinn (Ed.).
Handbook of Pharmaceutical Exipients, 6th Ed. London:
Pharmaceutical Press. 2009. 17 - 19, 385 - 7,
549 - 53, 675 - 8, 766 - 70.

14. Shaji J and Sharvari Garude. Transethosomes and
Ethosomes for Enhanced Transdermal Delivery of
Ketorolac Tromethamine : A Comparative Assessment.
International Journal of Current Pharmaceutical
Research. 2014. 6 (4), 88 - 93.

15. Shen S, Liu SZ, Zhang YS, Du MB, Liang AH,
Song LH and Zu Guang Ye. Compound Antimalarial
Ethosomal Cataplasm: Preparation, Evaluation, and
Mechanism of Penetration Enhancement. International
Journal of Nanomedicine. 2015. 10, 4249 - 53

16. Song CK, Balakrishnan P, Shim CK, Chung SJ,
Chong S and Dae Duk Kim. A Novel Vesicular Carrier,
Transethosome, for Enhanced Skin Delivery of
Voriconazole : Characterization and In Vitro / In Vivo
Evaluation. Colloids and Surface B: Biointerfaces.
2012. 92, 299 - 304.

17. Touitou E, Godin B, Weiss C. Enhanced Delivery of
Drugs Into and Across The Skin by Ethosomal Carriers.
Drug Development Research. 50 (3 - 4), 406 - 15.
Published
2020-10-28
How to Cite
SRIFIANA, Yudi; AMALIA, Anisa; YUSNIA, Yusnia. Physical Stability of Curcumin Transethosome Using Combinations Tween 60 and Span 60 as Surfactant. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 18, n. 2, p. 184-191, oct. 2020. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/796>. Date accessed: 31 dec. 2024. doi: https://doi.org/10.35814/jifi.v18i2.796.
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