Preparation and Characterization of Mefenamic Acid Microcapsule using Sodium Alginate Polymer by Ionic Gelation Methods

  • Sandra Aulia Mardikasari Fakultas Farmasi, Universitas Hasanuddin
  • Suryani Suryani Fakultas Farmasi, Universitas Halu Oleo
  • Marwah Puspitasari Fakultas Farmasi, Universitas Halu Oleo

Abstract

Mefenamic acid belongs to a class of the non-steroidal anti-infl ammatory drugs that work as
an analgesic. Mefenamic acid is sensitive to the light and temperature, also has unpleasant odors and
tastes. Microencapsulation technology is a technique where the active substance is coated by a thin layer
so that the active substance is protected from environmental infl uences. The aim of this research was to
formulate and characterize mefenamic acid in the form of microcapsule using ionic gelation methods
with sodium alginate. Preparation was done by comparing the concentrations of sodium alginate
polymers namely, 1%, 2%, and 3%. Success parameters include the entrapment effi ciency, particle
shape, particle size distribution, and dissolution. The results on the entrapment effi ciency using UVVIS
spectrophotometer showed a concentration of 1% polymer has a high value of 94.02%, for particle
shapes using the optical microscope showed that three formulas were spherical with the smallest particle
size distribution was 1266 μm. The dissolution test by type II dissolution test showed that the higher
the concentration of polymer used, the slower the drug release. This research provides an alternative
formulation of mefenamic acid microcapsule by using sodium alginate polymer.

References

1. Chandra, C. Studi penggunaan obat analgesik pada
pasien cedera kepala (concussion) di Rsup Prof. Dr.
RD Kandou Manado periode Januari-Desember 2014.
PHARMACON. 2016. 5(2).

2. Meliala, L. Nyeri: keluhan yang terabaikan konsep
dahulu, sekarang dan yang akan datang. Fakultas
Kedokteran UGM. Yogyakarta. 2004.

3. Indrawati T, Sari NK. Stabilitas kaplet asam mefenamat
dengan suhu dan kelembaban ruang penyimpanan
yang berbeda. Makara Kesehatan. 2010. 14(2): 75-80.

4. Posangi J, Hutagalung BS. Uji efek pemberian asam
mefenamat sebelum pencabutan gigi terhadap durasi
ambang nyeri setelah pencabutan gigi. e-GiGi. 2015.
3(2).

5. Azhar R, Yunengsih E, Halim A. Mikroenkapsulasi
parasetamol dengan polimer hidroxy prophyl methyl
celluloce (HPMC) menggunakan metoda penguapan
pelarut. Jurnal Farmasi Higea. 2010. 2(2):137-45.

6. Poshadri A, Aparna K. Microencapsulation technology:
a review. Journal of Research ANGRAU. 2010.
38(1):86-102.

7. Poshadri A, Aparna K. Microencapsulation technology:
a review. Journal of Research ANGRAU. 2010.
38(1):86-102.

8. Patil P, Chavanke D, Wagh M. A review on ionotropic
gelation method: novel approach for controlled
gastroretentive gelispheres. Int J Pharm Pharm Sci.
2012. 4(4):27-32.

9. Ubaiillah Syaikhul AM. Pengaruh konsentrasi agen
pengikat silang terhadap karakteristik pirasinamid
terenkapsulasi. Unesa Journal of Chemistry. 2015.
4(1).

10. Rusnaeni R, Sinaga DI, Lanuru F, Payungallo IM,
Ulfi ani II. Identifi kasi asam mefenamat dalam jamu
rematik yang beredar di distrik Heram kota Jayapura,
Papua. PHARMACY: Jurnal Farmasi Indonesia. 2016.
13(1):84-91.

11. Jyothi SS, Seethadevi A, Prabha KS, Muthuprasanna P,
Pavitra P. Microencapsulation: a review. Int. J. Pharm.
Biol. Sci. 2012. 3:509-31.

12. Noviza D, Harliana T, Rasyad AA. Mikroenkapsulasi
metformin hidroklorida dengan penyalut etil selulosa
menggunakan metode penguapan pelarut. Jurnal Sains
& Teknologi Farmasi. 2013. 18(1):75-9.

13. Kurniawan R, rahmat D. Mikroenkapsulasi controlled
release lansoprazol dengan kombinasi hydroxy propyl
methyl cellulose phthalate dan natrium alginat secara
gelasi ionotropik. Jurnal Ilmu Kefarmasian Indonesia.
2017.14(1):86-92.

14. Firdyawati S FS. Formulasi mikropartikel teofi lin
menggunakan penyalut kitosan-alginat yang dipaut
silang dengan natrium tripolifosat (disertasi doktoral,
Universitas Islam Negeri Alauddin Makassar). 2014.

15. Mardikasari SA, Akib NI, Indahyani R. Preparasi
dan karakterisasi mikroenkapsulasi asam mefenamat
menggunakan polimer kitosan dan natrium alginat
dengan metode gelasi ionik. Jurnal Farmasi Galenika.
2020. https://doi.org/10.22487/j24428744.v.i.1458

16. Nerdy N. Validation of ultraviolet spectrophotometry
method for determination of mefenamic acid level
in suspension dosage forms. Jurnal Natural. 2017.
17(1):17-22.

17. Octavia MD, Zaini E, Oktavia V. Studi sistem dispersi
padat asam mefenamat menggunakan polivinil
pirolidon K-30. Jurnal Farmasi Higea. 2017. 7(2):173-
80.

18. Wahyuni R, Halim A, Irawati YS. Mikroenkapsulasi
karbamazepin dengan polimer HPMC menggunakan
metoda emulsifikasi penguapan pelarut. Jurnal
Farmasi Higea. 2017. 7(2):190-207.
Published
2020-10-28
How to Cite
MARDIKASARI, Sandra Aulia; SURYANI, Suryani; PUSPITASARI, Marwah. Preparation and Characterization of Mefenamic Acid Microcapsule using Sodium Alginate Polymer by Ionic Gelation Methods. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 18, n. 2, p. 192-197, oct. 2020. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/797>. Date accessed: 02 dec. 2020. doi: https://doi.org/10.35814/jifi.v18i2.797.
Section
Articles