Estrogenic Mechanism Study of Combination of Basil and Fennel Extract through Ovarian Histopathic and Uterus

  • Yulianita Yulianita Fakultas MIPA Universitas Pakuan
  • E. Mulyati Effendi Fakultas MIPA Universitas Pakuan
  • Triastinurmiatiningsih Triastinurmiatiningsih Fakultas MIPA Universitas Pakuan

Abstract

Research on the Estrogenic Mechanism Study of the Combination of Basil Herb (Ocimum
americanum) and Fennel Fruit (Foeniculum vulgare) against the background of research results which
showed that the combination of 70% ethanol extract of basil herbs 0.35g / 200g BB and fennel fruit
0.0725g / 200g BB had effi cacy estrogenic because it greatly aff ects the duration of the estrus phase,
vascularization and weight of the ovaries and uterus. The aim and target to be achieved from this
research is to know the working mechanism of the combination of estrogenic basil and fennel fruit
herbs. The parameters observed were histopathological examination of the ovary and uterus. Histopathic
test results in the ovary and uterus show the eff ect of treatment on the development of follicles in the
ovary and uterine wall thickening. So it can be concluded that the mechanism of estrogenic combination
of basil and fennel fruit extracts occurs through the mechanism of genomics, where phytoestrogen
compounds in both plants pass through cell membranes and interact with receptors so that they can
produce estrogen-like eff ects.

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Published
2020-10-28
How to Cite
YULIANITA, Yulianita; EFFENDI, E. Mulyati; TRIASTINURMIATININGSIH, Triastinurmiatiningsih. Estrogenic Mechanism Study of Combination of Basil and Fennel Extract through Ovarian Histopathic and Uterus. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 18, n. 2, p. 213-219, oct. 2020. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/822>. Date accessed: 02 dec. 2020. doi: https://doi.org/10.35814/jifi.v18i2.822.
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