Estrogenic Mechanism Study of Combination of Basil and Fennel Extract through Ovarian Histopathic and Uterus

  • Yulianita Yulianita Fakultas MIPA Universitas Pakuan
  • E. Mulyati Effendi Fakultas MIPA Universitas Pakuan
  • Triastinurmiatiningsih Triastinurmiatiningsih Fakultas MIPA Universitas Pakuan
DOI: https://doi.org/10.35814/jifi.v18i2.822

Abstract

Research on the Estrogenic Mechanism Study of the Combination of Basil Herb (Ocimum
americanum) and Fennel Fruit (Foeniculum vulgare) against the background of research results which
showed that the combination of 70% ethanol extract of basil herbs 0.35g / 200g BB and fennel fruit
0.0725g / 200g BB had effi cacy estrogenic because it greatly aff ects the duration of the estrus phase,
vascularization and weight of the ovaries and uterus. The aim and target to be achieved from this
research is to know the working mechanism of the combination of estrogenic basil and fennel fruit
herbs. The parameters observed were histopathological examination of the ovary and uterus. Histopathic
test results in the ovary and uterus show the eff ect of treatment on the development of follicles in the
ovary and uterine wall thickening. So it can be concluded that the mechanism of estrogenic combination
of basil and fennel fruit extracts occurs through the mechanism of genomics, where phytoestrogen
compounds in both plants pass through cell membranes and interact with receptors so that they can
produce estrogen-like eff ects.

References

1. Pudiastuti RD. Tiga Fase Penting pada Wanita (menarche, menstruasi dan menopause). Jakarta: PT Elex Media Komputindo; 2012.

2. Suparni IE dan Astutik RY. Menopouse Masalah dan Penangannya. Yogyakarta: Deepublish; 2016.

3. Biben HA. Fitoestrogen: Khasiat Terhadap Sistem Reproduksi, Non Reproduksi dan Keamanan Penggunaannya. disampaikan pada Seminar Ilmiah Nasional Estrogen sebagai Sumber Hormon Alami, Bandung 31 Maret 2012.

4. [EMEA] European Medicines Agency Evaluation of Medicines for Human Use. Assessment report on Foeniculum vulgare Miller. London: Europian Medicine Agency; 2008.

5. Pandey G and Madhuri S. Pharmacological Activities of Ocimum sanctum: a Review. International Journal of Pharmaceutical Science Review and Research. 2010. 5 (1): 61-66.

6. Maheshwari H., Astuti P dan Effendi M. Kajian Khasiat Estrogenik Ekstrak Etanol Buah Adas (Foeniculum Vulgare Mill.) pada Tikus Putih Betina. Penelitian Fundamental, Lembaga Penelitian dan Pengabdian Kepada Masyarakat IPB Bogor. 2009.

7. Effendi EM., Maheshwari H dan Indra MLM. Uji Aktivitas Estrogenik Ekstrak Etanol 70% Herba Kemangi (Ocimum americanum. L.) Pada Tikus Putih (Rattus norvegicus) Betina Pre-Menopause. Jurnal Fitofarmaka. 2011. 1(1): 1-6.

8. Effendi EM., Maheshwari H dan Husna M. Potensi Estrogenik Kombinasi Ekstrak Etanol 70% Herba Kemangi (Ocimum americanum. L.) dan Buah Adas (Foeniculum Vulgare Mill.) Pada Tikus Putih (Rattus norvegicus) Betina Pre-Menopause. Jurnal Ekologia 2015. 15 (2): 21-32

9. Hanani E. Analisis Fitokimia. Jakarta: Penerbit Buku Kedokteran EGC; 2014

10. Hafez. Atlas Of Human Reproduction : By Scanning Electron Microscopy. USA: Mtp. Press; 2012.

11. Syamsudin dan Darmono. Buku Ajar Farmakologi Eksperimental. Jakarta: UI Press; 2011.

12. Mutschler, E. Dinamika Obat, Edisi ke-5. Penerjemah Mathilda dan Anna . Bandung: ITB Press; 1991.

13. Setiawan M. Nutrisi Kedelai Pada Obesitas Dan Dismetabolik Sindrom. Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. 2010. 6 (2): 1-8.

14. Dusza L. Ciersezco R. Skarzinski DJ. Nogowski L. Opalka M. et.al. Mechanism of Phytoestrogen action in reproductive processes of mamals and bird. The Society for Biology of Reproduction. 2006. 6 (1): 151-173.

15. Dellmann HD dan Brown EM. Buku Teks Histologi Veteriner II. Edisi 3. Alih bahasa : R. Hartono. Jakarta: UI Press; 1992.

16. Mardiati SM dan Sitasiwi AJ. Korelasi Jumlah Folikel Ovarium dengan Konsentrasi Hormon Estrogen Mencit (Mus musculus) setelah Konsumsi Harian Tepung Kedelai selama 40 Hari. Buletin Anatomi dan Fisiologi. 2008. 16 (2): 54-59.

17. Nurulita E. Prihatin J. Anam K. Octavia FARH. Perubahan Kadar Estradiol dan Histologi Mencit Betina dengan Induksi Progesteron Sintetik. Biosfera. 2107. 34 (3): 12-19.

18. Nurlita E. Prihatin J. Kontrasepsi Oral: Jenis, Fisiologi dan Pengaruhnya pada Rahim. Jember: UPT Penerbit Universitas Jember; 2017.
Published
2020-10-28
How to Cite
YULIANITA, Yulianita; EFFENDI, E. Mulyati; TRIASTINURMIATININGSIH, Triastinurmiatiningsih. Estrogenic Mechanism Study of Combination of Basil and Fennel Extract through Ovarian Histopathic and Uterus. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 18, n. 2, p. 213-219, oct. 2020. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/822>. Date accessed: 22 dec. 2024. doi: https://doi.org/10.35814/jifi.v18i2.822.
Citation Formats
Issue
Vol 18 No 2 (2020): JIFI
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.