Enhancement Allisin Diffusion Rate in The Garlic Extract Phytosome System

  • Anisa Amalia Fakultas Farmasi dan Sains, Universitas Muhammadiyah Prof. DR. HAMKA
  • Rahmah Elfiyani Fakultas Farmasi dan Sains, Universitas Muhammadiyah Prof. DR. HAMKA
  • Adesi Chenia Fakultas Farmasi dan Sains, Universitas Muhammadiyah Prof. DR. HAMKA
DOI: https://doi.org/10.35814/jifi.v19i1.842

Abstract

Garlic (Allium sativum L) contains allicin which has the property of reducing blood sugar levels. In previous studies, methanol extract of garlic can reduce blood sugar levels in mice at a dose of 400 mg/kg BW. Penetration of allicin can be increased by formulating extracts in the phytosome system. In this study, it will be observed the effect of making a phytosome system on the diffusion rate of allicin. Garlic extract phytosome was made using a thin layer hydration method which was then evaluated for its physicochemical properties which included testing of entrapment efficiency, density, particle size, index polydispersity, and zeta potential. Determination of the value of the diffusion rate of allicin in the extract and in the phytosome system was carried out using a modified diffusion cell for 420 minutes. The phytosome system formed has an entrapment efficiency value of 64.8789% with a density of 1.0051 g/mL, the particle size of 270 nm, the zeta potential of -32.55 mV and polydispersion index of 0.571. Diffusion rate testing indicates the diffusion rate of the phytosome system can increase the diffusion rate of allicin when compared to the diffusion rate of allicin in garlic extract.


 

References

Akter F and Rahmatullah M. Antihyperglycemic Activity Studies with Malva Verticillata Leaves from World Journal of Pharmaceutical Research. 2018. 7 (19): 107-113.
Amin T and Bhat SV. A review of phytosome technology as a novel approach to improve the bioavailability of nutraceuticals from Int J Adv Res Technol. 2012. 1(3): 1-5.
Amit P, Tanwar YS, Rakesh S and Poojan P. (2013). Phytosome: Phytolipid Drug Delivery System for Improving Bioavailability of Herbal Drugs from Journal of Pharmaceutical Science and Bioscientific Research (JPSBR). 2013. 3(2): 51-57
Annajiah W. Evaluasi Profil Disolusi Sediaan Lepas Lambat Diltiazem Hidroklorida yang Beredar Di Pasaran. Skripsi. Jakarta: FKIK Universitas Islam Negri Syarif Hidayatullah. 2015. Hlm. 22-23
Anwar E and Farhana N. 2018. Formulation and Evaluation of Phytosome-Loaded Maltodextrin-Gum Arabic Microsphere System for Delivery of Camellia sinensis Extract from Journal of Young Pharmacists. 2018. 10(2S): s56-s62
Departemen Kesehatan Republik Indonesia. Farmakope Herbal Indonesia Edisi I. Jakarta: Departemen Kesehatan Republik Indonesia. 2008. Hlm. 6 - 9, 98-103, 110-111, 150 - 163, 171, 174 – 175.
Departemen Kesehatan Republik Indonesia. Farmakope Indonesia. Edisi V Jakarta: Direktorat Jendral Pengawasan Obat dan Makanan. 2014. Hlm. 47, 399, 856, 1070, 1553, 1563, 1750.
Garg A, Aggarwal D, Garg S and Sigla AK. Spreading of Semisolid Formulation, An update form Pharmaceutical Technology North America. 2002. 26: 84-105.
Keerthi B, Pingali PS and Srinivas P. Formulation and evaluation of capsules of ashwagandha phytosomes form Int J Pharm Sci Rev Res. 2014. 29(2): 138-142.
Mitkari BV, Korde SA, Mahadik KR and Kokare CR. Formulation and evaluation of topical liposomal gel for fluconazole. Dalam: Indian J Pharm Educ Res. 2010. 44(4): 324-333.
Octavia, N. Formulasi Sediaan Gel Hand Sanitizer Minyak Atsiri Pala (Myristica fragrans Houtt.): Uji Stabilitas Fisik Dan Uji Aktivitas Antibakteri Terhadap Bakteri Staphylococcus aureu. dalam Journal Universitas Muhammadyah Surakarta. Surakarta. 2016. Hlm. 1-15
Ramadon D and Mun’im A. Pemanfaatan nanoteknologi dalam sistem penghantaran obat baru untuk produk bahan alam dalam Jurnal Ilmu Kefarmasian Indonesia. 2016. 14(2): 118-127
Saha S, Sarma A, Saikia P and Chakrabarty T. Phytosome: A Brief Overview form Journal Scholars Academic Journal of Pharmacy (SAJP). 2013. 2(1): 12-20.
Sayuti NA. Formulation and Physical Stability of Cassia alata L. Leaf Extract Gel dalam: Jurnal Kefarmasian Indonesia. Jakarta. 2015.5: 77.
Setiawan AS, Yulinah E, Adnyana K, Permana H dan Sudjana P. Efek antidiabetes kombinasi ekstrak bawang putih (Allium sativumLinn) dan rimpang kunyit (Curcumma domestica Val.) dengan pembanding Glibenklamid pada penderita diabetes mellitus tipe 2. MKB. 2011. 43(1): 26-34.
Shaikh H K, Kshirsagar RV and Patil SG. Mathematical models for drug release characterization: a review form World J. Pharm. Pharm. Sci. 2015. 4(4): 324-338.
Singla V, Saini S, Joshi B and Rana AC. Emulgel : A New Platform For Topical Drug Delivery form International Journal of Pharma and Bio Sciences. 2012. 3(1): 485-498.
Published
2021-04-19
How to Cite
AMALIA, Anisa; ELFIYANI, Rahmah; CHENIA, Adesi. Enhancement Allisin Diffusion Rate in The Garlic Extract Phytosome System. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 19, n. 1, p. 1-8, apr. 2021. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/842>. Date accessed: 25 apr. 2024. doi: https://doi.org/10.35814/jifi.v19i1.842.
Citation Formats
Issue
Vol 19 No 1 (2021): JIFI
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.