Formulation and Activity of Gel Containing Nanoparticles of Javanese Turmeric Extract as Antiacne

  • Anastasya Anastasya Universitas Pancasila
  • Deni Rahmat Universitas Pancasila
  • Anarisa Budiati Universitas Pancasila

Abstract

 Javanese turmeric is one of the Indonesia’s authentic plant that has many benefits, antimicrobial effect is one of them. Curcuminoid and xanthorrhizol contents are responsible for it's antimicrobial activity. Acne vulgaris is one of skin’s disorder that caused by bacteria, the major cause is Propionibacterium acnes. This study aimed to compare antimicrobial activity difference between nanoparticle and extract gel. Javanese turmeric was extracted and then formulated into nanoparticles. Javanese turmeric extract and it's nanoparticles were then  formulated in gel preparation. Gel preparations were evaluated physically (organoleptic, homogeinity, spreadibility, and viscosity and rheology), chemically (pH value), and tested for their antimicrobial activity. Gel evaluations showed that both formula (nanoparticle and extract gel formula) did not show any discoloration and still homogeny. Extract gel formula had viscosity about 1540–1600 Ps, while nano extract gel had viscosity in the range of 487.63–501.01Ps. Extract gel formula had spreadability in the range of 51.75-53.35  mm,  while nano extract gel has viscosity in the range of 65.125-72.75 mm. Extract gel formula had pH value in the range of 5.98–6.02, while nano extract gel had pH value in the range of 5.88–5.93. Extract gel formula has inhibition zone in the range of 10.0 mm–10.3 mm, while nanoextract gel has inhibition zone in the range of 13.0 mm–13.4 mm. Based on statistical paired sample t-test analysis, nano extract gel formula was signifi cantly different from extract  gel formula in antimicrobial activity.

References

1. Abdalla, Emad M. Plants: An alternative Source for Antimicrobial. Journal of Applied Pharmaceutial Science. 2011;01(06); 16-20.

2. Harit J., et.al. Antimicrobial Activity of Rhizome of Selected Curcuma Variety. International Journal of Life Science Biotechnology and Pharma Research. Jurnal Ilmu Kefarmasian Indonesia 126Vol 18, 2020

3. Diastuti, Hartini, et.al. Antibacterial Curcuma xanthorrhiza Extract and Fraction. ITB Journal Publisher. 2014;46(3);224-234.

4. Singh M, Singh S, Prasad S, Gambhir IS. 2008. Nanotechnology in medicine and antibacterial eff ect of silver nanoparticles. Digest Journal of Nanoparticles and Biostructures 3: 115-122.

5. Sherwood L. Fisiologi manusia Dari sel ke sistem. Ed 6. Diterjemahkan oleh Pendit BU. Jakarta: Penerbit buku kedokteran EGC; 2009, hlm. 654-60, 675-77.

6. Tiyaboonchai, Waree. Kitosan Nanoparticles: A Promising System for Drug Delivery. Naresuan University Journal 2003; 11(3): 51-66.

7. MM. Reiger. 2000. Harry’s Cosmeticology, 8th ed. New York: Chemical Publishing Company.

8. Jawetz, E.L. dan E.A. Adelberg. 2001. Mikrobiologi Kedokteran buku ke 22 Terjemahan dari Medical Microbiology, Twenty Second Edition oleh bagian Mikrobiologi Fakultas Kedokteran Universitas Airlangga. Jakarta: Salem Medika. h. 161-250.
Published
2020-04-29
How to Cite
ANASTASYA, Anastasya; RAHMAT, Deni; BUDIATI, Anarisa. Formulation and Activity of Gel Containing Nanoparticles of Javanese Turmeric Extract as Antiacne. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 18, n. 1, p. 118-122, apr. 2020. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/846>. Date accessed: 19 oct. 2020. doi: https://doi.org/10.35814/jifi.v18i1.846.
Section
Articles