Formulation And Test Of Anti-Aging Activity Aloe Vera (Aloe vera Linn.) Gel
Abstract
Aging is one of the problems that occurs in the skin. The factors cause aging are either free radicals. The use of antioxidants can prevent aging. Mucous Aloe vera known to have an antioxidant effect. The purpose of this study is to get aloe vera gel that stable and has anti-aging effects. This research was conducted by making a gel of aloe vera preparations in three formulas, each with aloe vera mucous of 5% (F1), 15% (F2) and blank (F0). Evaluation of gel preparations includes organoleptic, pH, Stability checks at room and cold temperatures, Scatter test, Adhesion, homogenity, irritation and anti-aging test on the skin of the backs of volunteers using skin analyzer with measured parameters including moisture, evenness, large pores, spot, and wrinkles. Gel was used twice a day for 30 days and was carried out every week. Statistical data were analyzed using the two-way ANOVA and continued with the Tukey test. The results showed that the stable a gel of aloe vera formula was F2 with a aloe vera concentration of 15%. Anti-aging activity test results showed that aloe vera gel preparations 15% (F2) faster recovery in increasing moisture, skin smoothness, shrinking pore size, reducing spot and wrinkles.
References
reviews. 2019. 2(8).
2. Kammeyer A, Luiten RM. Oxidation events and skin aging. Ageing research review. 2015. 21:16-29
3. Iskandar, B., Sidabutar Santa Eni, Br., Leny. 2021. Formulasi dan evaluasi lotion ekstrak alpukat (Persea
americana) sebagai pelembab kulit. Journal of Islamic Pharmacy. 2021. 6(1):16-21.
4. Salawu, K. M., Ajaiyeoba, E. O., Oluyemisi, O., Adeniji, J. A., & Faleye, T. C. Antioxidant, brine
shrimp lethality, and antiproliferative properties of gel and leaf extracts of Aloe schweinfurthii and Aloe vera
antioxidant, brine shrimp lethality, and antiproliferative and Aloevera. Journal of Herbs, Spices & Medicinal
Plants. 2017. 00(00):1–9.
5. Arikumalasari, J; Dewantara, I G.N.A dan Wijayanti, N.P.AD. Optimasi HPMC sebagai gelling agent dalam
formula gel ekstrak kulit buah manggis (Garcinia mangostana L.). Naskah Publikasi. 2013. h.145-148.
6. Anastasya., Rahmat, D., Budiati, A. Formulasi dan aktivitas gel yang mengandung nanopartikel ekstrak
temulawak sebagai antiacne. Jurnal ilmu kefarmasian Indonesia. 2020. 18(1):118-122.
7. Amatullah, L., Cahyaningrum, T., dan Fidyaningsih, A. Efektifi tas antioksidan pada formulasi skin lotion
ekstrak mesocarp buah lontar (Borassus fl abellifer) terhadap tikus putih jantan galur wistar secara insitu.
Skripsi. Surakarta: Akademi Farmasi Nasional Surakarta. 2017.
8. Ardhie, M.A. Radikal bebas dan peran antioksidan dalam mencegah penuaan. Jakarta: Scientific Journal
Of Pharmaceutical Development and Medical Application. 2011. 24(1): 4-9.
9. Rowe, R.C., Sheskey, P. J., and Quinn, M.E. Handbook of pharmaceutical excipients. 6th ed. London: The
Pharmaceutical Press. 2009.
10. Tranggono, R. I. dan Latifah, F. Buku pegangan ilmu pengetahuan kosmetik. 2nd ed. Jakarta: Gramedia
Pustaka Utama. 2018.
11. Aramo. Skin and hair diagnostic system. Sugnam: Aram Huvis Korea Ltd. 2012. h. 1-10.
12. Iskandar, B., Karsono., Silalahi, J. Preparation of spray nanoemulsion and cream containing vitamin E as
anti-aging product tested in vitro and in vivo method. International Journal PharmaTech Research. 2016.
9(6): 307-308.
13. Mappa, T., H.J., E. and K.N. Formulasi gel ekstrak daun sasaladahan (Peperomia pellucid L.) dan uji
efektivitasnya terhadap luka bakar pada kelinci Jurnal Ilmu Kefarmasian Indonesia
(Oryctolagus cuniculus), Jurnal Ilmiah Farmasi. 2013. 2(2):49–56.
14. Sultana, B. dan Anwar, F. Flavonol (kaempeferol, quercetin, merycetin) contents of selected fruit,
vegetables and medicinal plants. Food Chemistry. 2008. 108:879-88.
15. Iskandar, B., Putri, DD., Firmansyah, F., Frimayanti, N., Agustini, TT. Evaluasi sifat fisik dan uji kelembaban
sediaan losion yang dijual secara online shop. Jurnal dunia farmasi. 2019. 4(1):8-16.
16. Pravitasari, D. N. Efek Samping Kosmetik Dan Penanganannya. Jurnal Kedokteran Dan Kesehatan,
2010. 6(2).
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