Evaluation of Empirical Antibiotics Appropriateness to Wards for Antibiogram and Clinical Outcome Community Acquired Pneumonia (CAP) in Adults Patients

  • Mujiyanti Mujiyanti Universitas Ahmad Dahlan
  • Dyah Aryani P. Universitas Ahmad Dahlan
  • Endang Darmawan Universitas Ahmad Dahlan
  • Irma Risdiana Universitas Ahmad Dahlan

Abstract

The mortality rate for Community-Acquired Pneumonia (CAP) in Indonesia is in the fourth rank
and the top ten diseases each year. The main therapeutic principle of CAP is the administration of antibiotics.
Improper antibiotic usage can aff ect the success of therapy. The pattern of antibiotics used in hospitals is usually based on clinical and empirical experience, not based on the germ pattern and the sensitivity of antibiotics. The study aims to describe the suitability of empiric antibiotics against the antibiogram profi le and treatment outcomes in inpatients with CAP at PKU Muhammadiyah Gamping Hospital. This study was conducted under the descriptive-analytic observational study design with a retrospective cohort design where the data source came from secondary data, namely the medical records of community pneumonia patients in 2019 and hospital antibiogram data. The data were collected by using the total sampling method. There were 79 community pneumonia patients. The results of the empirical antibiotic suitability test results on antibiograms and clinical outcomes showed that there was no signifi cant relationship between the suitability of empirical antibiotics to the clinical outcome of leukocytes (p = 0.550; RR = 0.725; 95% CI = 0.252-2.086), clinical outcome temperature (p= 0.545; RR = 0.576; 95% CI = 0.049-6.747) and clinical outcome length of stay (p = 0.631; RR = 0.767; CI95= 0.258-2.275). The conclutions there was no signifi cant relationship between the appropriateness of empirical using of antibiotics and antibiogram profi le include leukocyte, temperature and length of stay of the patients (p>0.05).

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Published
2021-04-30
How to Cite
MUJIYANTI, Mujiyanti et al. Evaluation of Empirical Antibiotics Appropriateness to Wards for Antibiogram and Clinical Outcome Community Acquired Pneumonia (CAP) in Adults Patients. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 19, n. 1, p. 102-110, apr. 2021. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/920>. Date accessed: 28 sep. 2021. doi: https://doi.org/10.35814/jifi.v19i1.920.
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