Evaluation of Empirical Antibiotics Appropriateness to Wards for Antibiogram and Clinical Outcome Community Acquired Pneumonia (CAP) in Adults Patients

  • Mujiyanti Mujiyanti Universitas Ahmad Dahlan
  • Dyah Aryani Perwitasari Universitas Ahmad Dahlan
  • Endang Darmawan Universitas Ahmad Dahlan
  • Irma Risdiana Universitas Ahmad Dahlan


The mortality rate for Community-Acquired Pneumonia (CAP) in Indonesia is in the fourth rank
and the top ten diseases each year. The main therapeutic principle of CAP is the administration of antibiotics.
Improper antibiotic usage can aff ect the success of therapy. The pattern of antibiotics used in hospitals is usually based on clinical and empirical experience, not based on the germ pattern and the sensitivity of antibiotics. The study aims to describe the suitability of empiric antibiotics against the antibiogram profi le and treatment outcomes in inpatients with CAP at PKU Muhammadiyah Gamping Hospital. This study was conducted under the descriptive-analytic observational study design with a retrospective cohort design where the data source came from secondary data, namely the medical records of community pneumonia patients in 2019 and hospital antibiogram data. The data were collected by using the total sampling method. There were 79 community pneumonia patients. The results of the empirical antibiotic suitability test results on antibiograms and clinical outcomes showed that there was no signifi cant relationship between the suitability of empirical antibiotics to the clinical outcome of leukocytes (p = 0.550; RR = 0.725; 95% CI = 0.252-2.086), clinical outcome temperature (p= 0.545; RR = 0.576; 95% CI = 0.049-6.747) and clinical outcome length of stay (p = 0.631; RR = 0.767; CI95= 0.258-2.275). The conclutions there was no signifi cant relationship between the appropriateness of empirical using of antibiotics and antibiogram profi le include leukocyte, temperature and length of stay of the patients (p>0.05).


1. Vos T, Barber RM, Bell B, Bertozzi-Villa A, Biryukov S, Bolliger I, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet [Internet]. 2015;386(9995):743–800. Available from: http://dx.doi.org/10.1016/S0140-6736(15)60692-4

2. Kementrian Kesehatan RI. Profi l Kesehatan Indonesia. Jakarta Pusat; 2013.

3. Rahayu YD, Wahyono D, Mustofa. Evaluasi Rasionalitas Penggunaan Antibiotik Terhadap Luaran Pada
Pasien Anak Penderita Pneumonia. JournalUgmAcId [Internet]. 2014;4(1):264–70. Available from:

4. Pratama A. Evaluasi kesesuaian penggunaan antibiotik empiris pada pasien Community Acquired Peumonia
(CAP) Rawat inap di RSUP Dr. Sardjito Yogyakarta serta Antibiogramnya. 2016;

5. Joshi S. Hospital antibiogram: A necessity. Indian J Med Microbiol. 2010;28(4):277–80.

6. Sari MA, Raveinal R, Noverial N. Derajat Keparahan Pneumonia Komunitas pada Geriatri Berdasarkan
Skor CURB-65 di Bangsal Penyakit Dalam RS. Dr. M. Djamil Padang Tahun 2016. J Kesehat Andalas. 2018;7(1):102.

7. Putri RM, Hasan H. Tinjauan Imunologi Pneumonia pada Pasien Geriatri. Cdk-212. 2014;41(1):14–8.

8. López-de-Andrés A, Albaladejo-Vicente R, de Miguel- Diez J, Hernández-Barrera V, Ji Z, Zamorano-
León JJ, et al. Gender diff erences in incidence and in-hospital outcomes of community-acquired, ventilator-
associated and nonventilator hospital-acquired pneumonia in Spain. Int J Clin Pract. 2020;0–1.

9. Almirall J, Serra-Prat M, Bolíbar I, Balasso V. Risk Factors for Community-Acquired Pneumonia in
Adults: A Systematic Review of Observational Studies. Respiration. 2017;94(3):299–311.

10. Jalil ANA. Profi l Pasien Pneumonia Komunitas Rumah Sakit Umum Daerah Cengkareng. Univ Islam Negeri
Syarif Hidayatullah Jakarta. 2015.

11. Worotikan NI, Hasmono D, Kasih E, Ramdani D. Studi Penggunaan Sefalosporin Generasi Ketiga pada
Pasien Pneumonia di Instalasi Rawat Inap Rumah Sakit Umum Haji Surabaya Fakultas Farmasi , Universitas
Katolik Widya Mandala Surabaya , Surabaya , Indonesia Fakultas Farmasi , Universitas Airlangga Suraba.

12. Alfina LNRMR. Analisis Perbandingan Antara Monoterapi dengan Dualterapi Antibiotik Extended
Empiric pada Pasien Community-Acquired Pneumonia di RSUP Fatmawati Jakarta. J Sains Farm Klin
6(2),147–157. 2019;6(2):147–57.

13. Cillóniz C, Polverino E, Ewig S, Aliberti S, Gabarrús A, Menéndez R, et al. Impact of age and comorbidity on
cause and outcome in community-acquired pneumonia. Chest. 2013;144(3):999–1007.

14. Azmi S, Aljunid SM, Maimaiti N, Ali AA, Muhammad Nur A, De Rosas-Valera M, et al. Assessing the
burden of pneumonia using administrative data from Malaysia, Indonesia, and the Philippines. Int J Infect Dis [Internet]. 2016;49:87–93. Available from: http://dx.doi.org/10.1016/j.ijid.2016.05.021

15. Trinh HT, Hoang PH, Cardona-Morrell M, Nguyen HT, Vu DH, Dong PT, Cao TT, Nguyen ST, Pham VT,
Moss L, Dinh K, Dartnell J NH. Antibiotic therapy for inpatients with community-acquired pneumonia in a
developing country. Pharmacoepidemiol Drug Saf. 2, Nguyen HT. Antibiotic therapy for inpatients with
community-acquired pneumonia in a developing country.. ;:. do. Pharmacoepidemiol Drug Saf [Internet]. 24(2):129–36. Available from: https://pubmed.ncbi.nlm.nih.gov/24648269/

16. Faisal F, Burhan E, et. al. Penilaian Respons Pengobatan Empiris pada Pasien Rawat Inap dengan Pneumonia
Komunitas Evaluation of Empirical Treatment Responsse in Hospitalized Patient Community Acquired Pneumonia. J Respir Indo. 2014;34(2):60–70.

17. Capelastegui A, España PP, Bilbao A, Gamazo J, Medel F, Salgado J, et al. Etiology of community-acquired
pneumonia in a population-based study: Link between etiology and patients characteristics, process-of-care,
clinical evolution and outcomes. BMC Infect Dis. 2012;12.

18. Robinson SB, Ernst FR, Lipkin C, Huang X. Patient outcomes on day 4 of intravenous antibiotic therapy
in non-intensive care unit hospitalized adults with community-acquired bacterial pneumonia. Infect Dis Clin Pract. 2014;22(6):320–5.

19. Feri S. Analisis faktor-faktor yang mempengaruhi outcome terapi pasien pneumonia di Rumah Sakit Umum
Pusat Fatmawati Jakarta. 2019;5(3):5–10.

20. Welte T, Torres A, Nathwani D. Clinical and economic burden of community-acquired pneumonia among
adults in Europe. Thorax. 2012;67(1):71–9.
How to Cite
MUJIYANTI, Mujiyanti et al. Evaluation of Empirical Antibiotics Appropriateness to Wards for Antibiogram and Clinical Outcome Community Acquired Pneumonia (CAP) in Adults Patients. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 19, n. 1, p. 102-110, apr. 2021. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/920>. Date accessed: 16 apr. 2024. doi: https://doi.org/10.35814/jifi.v19i1.920.