Antidiarrheal Activity Test of White Pomegranate (Punica granatum L.) Infusion on Swiss Webster Male with Oleum Ricini Method

  • Nur Rahayuningsih STIKes BTH Tasikmalaya
  • Siti Nuurul Hidayah Assyifa Sekolah Tinggi Ilmu Kesehatan Bakti Tunas Husada Tasikmalaya
  • Ira Rahmiyani Sekolah Tinggi Ilmu Kesehatan Bakti Tunas Husada Tasikmalaya
DOI: https://doi.org/10.35814/jifi.v19i1.943

Abstract

Diarrhea is a condition in which a person defecates with a soft or liquid consistency, which can even
be water. Diarrhea can be treated with drugs derived from plants, one of which is white pomegranate skin. The
skin of white pomegranate (Punica granatum L.) is thought to have anti-diarrheal activity because it has fl avonoids
and tannins. This study aims to determine the activity and optimal dose of pomegranate skin infusion.
Mice were grouped into 5 groups: negative control (Na CMC 0.5%), positive control (Loperamid HCl), and
pomegranate peel infusion test group with a dose of 8 mg / 20 g mice BW, 16 mg / 20 g weight mice and 32 mg.
/ 20 gr BB mouse. Mice induced diarrhea with Oleum ricini, 30 minutes later the mice were given a test preparation.
The onset of diarrhea, stool consistency, diarrhea frequency, duration of diarrhea and stool weight were
measured every 30 minutes for 6 hours. The results showed that the fi rst dose (8 mg / 20 gr BW of mice) was
the optimal dose for the initial parameters of diarrhea and fecal weight, which means that there was a signifi cant
diff erence with negative control and positive control (<0.05). The parameters of stool consistency, frequency of
diarrhea and duration of occurrence of diarrhea showed no signifi cant diff erence between groups of 8 mg / 20 g
mice BW, 16 mg / 20 g mice BW and 32 mg / 20 g mice BW, negative control and positive control (p> 0, 05).

References

1. Departemen Kesehatan RI. Panduan Sosialisasi Tatalaksana Diare pada Balita. Jakarta: Kementerian
Kesehatan Republik Indonesia Direktorat Jenderal pengendalian Penyakit dan Penyehatan Lingkungan; 2011.

2. Sabrina GA, Probosari N. Daya Antibakteri Fraksi n-butanol Kulit Buah Delima Putih (Granati fructus
cortex) terhadap Streptococcus mutans (Antibacterial Activity of White Pomegranate Pericarp Streptococcus
mutans . 2015;3(3).

3. Junaidah. Uji Aktivitas Antibakteri Infusum Kulit Buah Delima putih (Punica granatum Linn) terhadap bakteri
Escherichia coli. 2017;6(1):54–7.

4. Warditiani. Data Tanaman dan Pengobatan pada Lontar Usada Rare. 1999;

5. D P. Belajar Praktis Analisis Parametrik dan Non Parametrik dengan SPSS. Yogyakarta: Gava Media; 2012.

6. Goodman, Gilman. Dasar Farmakologi Terapi. Edisi 10. Joel G Hardman, Limbird LE, editors. Jakarta:
EGC; 2007.

7. Tjay, Hoan T, Rahardja K. Obat-Obat Penting, Khasiat, Penggunaan dan Efek-efek sampingnya. Ke-6. Jakarta:
PT. Elex Media Komputindo; 2007.

8. Purwaningdyah YG, Widyaningsih TD, Wijayanti N. Efektivitas Ekstrak Biji Pepaya ( Carica papaya L .)
Sebagai Antidiare Pada Mencit yang Diinduksi Salmonella typhimurium Effectiveness of Papaya Seed Extract
( Carica papaya L ) as Antidiarrheal in Mice were Induced Salmonella typhimurium. 2015;3(4):1283–93.

9. Enda, W. G. Uji efek antidiare ekstrak etanol kulit batang salam (Syzygium polyanthum (wigh) Walp.)
Terhadap Mencit jantan. Jurnal Sains Dan Kesehatan (Universitas Sumatra Utara). 2013:56.

10. Fratiwi Y. The Potential Of Guava Leaf ( Psidium guajava L . ) For Diarrhea. 2015;4:113–8.

11. Z I. Pengantar Farmakologi Molekuler. Yogyakarta: Gadjah Mada University Press; 2008.
Published
2021-04-29
How to Cite
RAHAYUNINGSIH, Nur; ASSYIFA, Siti Nuurul Hidayah; RAHMIYANI, Ira. Antidiarrheal Activity Test of White Pomegranate (Punica granatum L.) Infusion on Swiss Webster Male with Oleum Ricini Method. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 19, n. 1, p. 62-67, apr. 2021. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/943>. Date accessed: 05 nov. 2024. doi: https://doi.org/10.35814/jifi.v19i1.943.
Citation Formats
Issue
Vol 19 No 1 (2021): JIFI
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.