Blood Glucose Level Reduction Effect of Boiled Asparagus (Asparagus offi cinalis L.) in Mice Induced by Alloxan

  • Rika Sari Dewi Universitas Pancasila
  • Lestari Rahayu Universitas Pancasila
  • Ni Made Dwi Sandhiutami Universitas Pancasila
  • Sondang Khairani Universitas Pancasila
  • Isti Atika Universitas Pancasila


Diabetes mellitus characterized by hyperglycemia whereas the condition for high blood glucose. In
Indonesia, there are a lot of medicinal plants that used as antidiabetic treatment. Medicinal plants are known have relatively few side eff ects compared to chemical based drugs. Asparagus (Asparagus offi cinalis L.) was reported to have fl avonoids and saponins compounds that could be functioned as antidiabetic. The aim of this research was to fi nd out the eff ect of boiled asparagus on blood glucose level in mice induced by Alloxan. This research used 30 male DDY strained mice, which were classifi ed into 6 groups, and each group consisted of 5 mice. These 6 groups were: normal control, negative control, positive control (Acarbose), the boiled asparagus with dose of 280, 560, and 840 mg/kgBW for 14 days. Blood glucose level of mice were observed on day-0, 8, 15, and 22. The results showed that Alloxan injection increased the level of blood glucose. Another result showed that boiled asparagus with dose of 280, 560 and 840 mg/kgBW reduced the level of blood glucose and the eff ect showed treatment groups doses of 560 dan 840 mg/kgBW had no signifi cantly diff erent with positive control group (Acarbose).


1. Lembaga Ilmu Pengetahuan Indonesia. Laporan Tahunan Pusat Penelitian Bioteknologi. Cibinong: LIPI;
2005. h. 36.

2. Joshi G, Rawat M, Bisht V, Negi J, Singh P. Chemical Constituents of Asparagus. Pharmacogn. 2010; 4(8):

3. Queve, CL. Medicinal Plant Monographs. The quave research Group. 2013; p. 91.

4. Zhao J, Zhang W, Zhu X, Zhao D, Wang K, Wang R, et al. The Aqueous Extract of Asparagus Officinalis
L. by-Product Exerts Hypoglycaemic Activity in Streptozotocin-Induced Diabetic Rats. J Sci Food Agric. 2011; 91: 2095-2099.

5. Zhang W, Wu W, Wang Q, Chen Y, Yue G. The Juice of Asparagus by-Product Exerts Hypoglycemic Activity
in Streptozotocin-Induced Diabetic Rats. Journal of Food Biochemistry. 2014; 38: 509-517.

6. Hafi zur RM, Kabir N, Chishti S. Asparagus Offi cinalis Extract Controls Blood Glucose by Improving Insulin
Secretion and Β-Cell Function in Streptozotocin- Induced Type 2 Diabetic Rats. British Journal of Nutrition.
2012; 108(9): 1586- 1595.

7. Wresdiyati T, Karmila A, Astawan M, Karnila R. Teripang Pasir Meningkatkan Kandungan Antioksidan
Superoksida Dismutase pada Pankreas Tikus Diabetes. J Vet. 2015; 16(1): 145-51.

8. Muchid A, Umar F, Ginting MN, Basri C, Wahyuni R, Helmi R, et al. Pharmaceutical Care untuk Penyakit
Diabetes Melitus. Jakarta: Direktorat Bina Farmasi Komunitas dan Klinik; 2005. h. 7-42.

9. Szkudelski T. The Mechanism of Alloxan and Streptozotocin Action in B Cells of The Rat Pancreas. Physiol
Res. 2001; 50: 536-46.

10. Pravala EN, Vankatesham A. Evaluation of Asparagus officinalis for Anti- Diabetic Activity in Rats. IJIPSR.
2017; 5(07): 1-9.
How to Cite
DEWI, Rika Sari et al. Blood Glucose Level Reduction Effect of Boiled Asparagus (Asparagus offi cinalis L.) in Mice Induced by Alloxan. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 19, n. 1, p. 56-61, apr. 2021. ISSN 2614-6495. Available at: <>. Date accessed: 19 may 2024. doi: