Activity of Achyranthes Aspera Linn. on Reduction of Cholesterol and Blood Glucose Levels in Insulin Resistance Animal Models

  • Daniek Viviandhari Universitas Muhammadiyah Prof. Dr. HAMKA
  • Maharadingga Maharadingga Universitas Muhammadiyah Prof. Dr. HAMKA
  • Farah Zahria Universitas Muhammadiyah Prof. Dr. HAMKA
  • Putri Hardiyanti Universitas Muhammadiyah Prof. Dr. HAMKA
DOI: https://doi.org/10.35814/jifi.v20i1.964

Abstract

The most common causative factor in patients with type 2 diabetes is insulin resistance. Achyranthes Aspera Linn. is known as a medicinal plant which has been shown based on previous research to reduce total cholesterol, triglyceride, and blood glucose levels, but the effective dose is not yet known in insulin resistance rats. Further study is necessary to ensure the effect and also the dose. The purpose of the research was to determine the activity of the extract in reducing levels of total cholesterol, triglycerides, blood glucose, and OGTT in insulin resistance rats. 7 groups (each group consist of 4 animals) were divided, i.e. normal control (not induced), negative group (given with Na-CMC 0.5%), positive group 1 (fenofibrate), positive group 2 (metformin HCl), extract group dose 250, 500, and 750 mg / kg BW for 14 days of treatment. Induction of insulin resistance using streptozotocin. Total cholesterol, triglyceride, blood glucose, and OGTT levels were measured using a clinical spectrophotometer.  Oneway ANOVA followed by the Tukey test were used to analyze the data.  Data indicated that the third dose extract (750 mg/kg BW) could lower total cholesterol, triglycerides, blood glucose, and OGTT with the percentages of reduction of 48.83%, 48.95%, and 61.31%, respectively, and at OGTT the smallest AUC value was 23,991 mg/dL per minute.

References

1. Riskesdas. Hasil Utama Riskesdas Penyakit Tidak Menular 2018. Has Utama Riskesdas Penyakit Tidak Menular. 2018;8.

2. Man REK, Gan AHW, Fenwick EK, Gan ATL, Gupta P, Sabanayagam C, et al. Prevalence, determinants and association of unawareness of diabetes, hypertension and hypercholesterolemia with poor disease control in a multi-ethnic Asian population without cardiovascular disease. Popul Health Metr. 2019;17(1):1–10.

3. DiPiro JT, Wells BG, Schwinghammer TL, DiPiro C V. Pharmacotherapy Handbook. 9th ed. United States of America: McGraw-Hill Education Companies; 2015. 66, 72–74, 161–175 p.

4. Price S., Willson LM. Patofisiologi: Konsep Klinis Proses Penyakit Kronis. Jakarta: Buku Kedokteran EGC; 2005.

5. Purwandari H. Hubungan Obesitas Dengan Kadar Gula Darah pada Karyawan Di RS Tingkat IV Madiun.
Efektor. 2014;1(25):65–72.

6. Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. Pharmacotherapy: A Pathophysiologic Approach. 2017. 762–826 p.

7. Kemenkes RI. Riset Kesehatan Dasar 2013. Jakarta: Balitbang Kemenkes RI; 2013.

8. Wang X, Yu C, Zhang B, Wang Y. The Injurious Effects of Hyperinsulinism on Blood Vessels. Cell Biochemistry and Biophysics. 2014.

9. Yuan H, Ma Q, Ye L, Piao G. The traditional medicine and modern medicine from natural products. Molecules. 2016;21(5).

10. Sarvesh CN, Fernandes J. Evaluation of antihyperlipidemic activity of leaves of Achyranthes aspera Linn. Using hyperlipidemic rats. Asian J Pharm Clin Res. 2017;10(4):211–5.

11. Khan N, Akhtar MS, Khan BA, De Andrade Braga V, Reich A. Antiobesity, hypolipidemic, antioxidant and hepatoprotective effects of Achyranthes aspera seed saponins in high cholesterol fed albino rats. Arch Med Sci. 2015;11(6):1261–71.

12. Kamalakkannan K, Balakrishnan V. Studies on the effect of antidiabetic activity of Achyranthes aspera L. on alloxan induced wistar rats. Int J Pharm Pharm Sci. 2015;7(9):61–4.

13. Lakshmi V, Mahdi AA, Mishra V, Agarwal SK. Biopharmaceutics and Therapeutic Challenges Antidiabetic Potential of Achyranthes Aspera Leaves in Rats. 2018;1(1):1–3.

14. Tatto D, Dewi NP, Tibe F. Efek Antihiperkolesterol dan Antihiperglikemik Ekstrak Daun Ceremai (Phyllantus acidus (L.) Skeels) pada Tikus Putih Jantan (Rattus norvegicus) Hiperkolesterol Diabetes. Galen J Pharm. 2017;3(2):157–64.

15. Purnomo Y. Potensi toleransi oral glukosa ekstrak biji kedelai (Glycine max), rimpang jahe (Zingiber officinale) dan kombinasinya pada tikus model diabetes. eJKI. 2018;7(1):45–50.

16. Hanani E. Analisis Fitokimia. Egc. Jakarta: Buku Kedokteran EGC; 2015.

17. Harborne JB. Metode Fitokimia : Penuntun Cara Modern Menganalisa Tumbuhan. Bandung: ITB; 1987.

18. Firdaus, Rimbawan, Marliyanti, S A, Roosita K. Model Tikus Diabetes yang Diinduksi Streptozotocin- Sukrosa untuk Pendekatan Penelitian Diabetes Gestasional. J MKMI. 2016;12(1):29–34.

19. Betteng R. Analisis Faktor Resiko Penyebab Terjadinya Diabetes Melitus Tipe 2 Pada Wanita Usia Produktif Dipuskesmas Wawonasa. J e-Biomedik. 2014;2(2).

20. Krishnakumari S, Priya K. Hypolipidemic Efficacy of Achyranthes aspera on Lipid Profile in Sesame oil fed Rats. Anc Sci Life. 2006;25(3–4):49–56.

21. Lakshmi V, Agarwal S, Mahdi A, Khanna A. Steroidal saponin from Chlorophytum nimonii (Grah) with lipid-lowering and antioxidant activity. Chronicles Young Sci. 2012;3(3):227.

22. Kumar A, Gnananath K, Gande S, Goud E, Rajesh P, Nagarjuna S. Anti-diabetic Activity of Ethanolic Extract of Achyranthes aspera Leaves in Streptozotocin induced diabetic rats. J Pharm Res. 2011;4(June):3124–5.

23. Njideka BE, Nwankwo AET, Ugochukwu NT. Use of Achyranthes aspera Linn tea as antidiabetic and hypolipidemic herbal tea. Int J Heal Sci Res. 2019;9(2):32–8.
Published
2022-04-29
How to Cite
VIVIANDHARI, Daniek et al. Activity of Achyranthes Aspera Linn. on Reduction of Cholesterol and Blood Glucose Levels in Insulin Resistance Animal Models. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 20, n. 1, p. 73-80, apr. 2022. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/964>. Date accessed: 27 july 2024. doi: https://doi.org/10.35814/jifi.v20i1.964.
Citation Formats
Issue
Vol 20 No 1 (2022): JIFI
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.