Physical Stability Test and Determination of Total Flavonoid Content of Watermelon (Citrullus lanatus) Fruit Mesocarp Extract Gel Preparation
Abstract
The content of flavonoids in the white skin or mesocarp of watermelon has antioxidant power so that the active substance can be used in the manufacture of cosmetics, one of which is a gel dosage form. This type of research is observational with a descriptive research design. The purpose of this study was to obtain data on the stability of the watermelon (Citrullus lanatus) mesocarp extract gel preparation using the cycling test method. Physical stability evaluations were carried out, including organoleptic, homogeneity, pH, adhesion, spreadability, and viscosity. The results showed that the organoleptic observation of the preparation was in the form of a semi-solid, had a characteristic aromatic odor of the extract, and had a brownish-yellow color. As for the test results for the entire homogeneous cycle, the average pH range is 4.75 - 5, adhesion is 2.45 - 3.96 seconds, dispersion is 5.59 - 6.67 cm, and viscosity is 5426 - 6830 cps, and total flavonoid content of the gel preparation was 5.27%. This study concluded that the gel preparation was physically stable before and after 12 days of storage and contained 5.27% flavonoids.
References
2. Gabriella B, Kanneth SA. Introduction To Cosmetic Formulation And Technology. New Jersey: John Wiley and Sons; 2015. 235–237 p.
3. Manriquez J, Cataldo K, Vera-Kellet C, Harz-Fresno I. Wringkles. BMJ Clin Evid. 2014;
4. Ahmad Z, Damayanti. Penuaan Kulit : Patofisiologi dan Manifestasi Klinis. Berk Ilmu Kesehat Kulit dan Kelamin – Period Dermatology Venereol. 2018;30(03):208–15.
5. Fatmawaty A, Michrun N, Radhia R. Teknologi Sediaan Farmasi. Yogyakarta: Deepublish; 2015.
6. Suryani, Putri AEP. Formulasi Dan Uji Stabilitas Sediaan Gel Ekstrak Terpurifikasi Daun Paliasa (Kleinhovia Hospita L.) Yang Berefek Antioksidan. Pharmacon. 2017;6(3):157–69.
7. Akintunde O., Thomas FC, Egunleti F. Phytochemical, antioxidant and Proximate analyses of Citrullus lanatus Rind Extracts. Niger J Chem Res. 2021;26:103–16.
8. Kistriyani L, Fauziyyah F, Rezeki S. Profil Release Enkapsulasi Antosianin, Flavonoid dan Fenolik pada Kulit Semangka Menggunakan Metode Spray Drying. Eksergi. 2020;17(2):33.
9. Priska M, Peni N, Carvallo L, Ngapa YD. Antosianin dan Pemanfaatannya. Cakra Kim (Indonesian E-Journal Appl Chem. 2018;6(2):79–97.
10. Barrowclough RA. The Effect of Berry Consumption on Cancer Risk. J Nutr Heal Food Eng. 2015;2(1):1–9.
11. Kar M, Yashu C, Rahul M, Rakesh K. Current Developments in Excipients Science: Implication of Quantitative Selection of Each Excipient in Product Development. In: Basic Fundamentals of Drug Delivery. America: Academic Press; 2019. p. 29–83.
12. Mochtar MMR, Anindi LN, Pemta T. Perbandingan carbomer dan CMC-Na sebagai Gelling-Agent pada Formulasi Hand Sanitizer Aloe Vera. J Sint. 2021;2:88–96.
13. Slamet S, Anggun BD, Pambudi DB. Uji Stabilitas Fisik Formula Sediaan Gel Ekstrak Daun Kelor (Moringa
Oleifera Lamk.). J Ilm Kesehat. 2020;13(2):115–22.
14. Titaley S, Fatimawali, Lolo WA. Formulasi dan Uji Efektivitas Sediaan Gel Ekstrak Etanol Daun Mangrove Api-api ( Avicennia marina ). Pharmacon J Ilm Farm – UNSRAT J Ilm Farm. 2014;3(2):99–106.
15. Tambunan S, Sulaiman TNS. Formulasi Gel Minyak Atsiri Sereh dengan Basis HPMC dan Karbopol Gel. Maj Farm. 2018;14(2):87–95.
16. Rahmatullah S, Slamet, Ningrum WA, Dewi NK. Formulasi dan Evaluasi Sediaan Gel Hand Sanitizer Sebagai Antiseptik Tangan dengan Variasi Basis Karbopol 940 Dan Tea. Pharm Sci J. 2020;3(3):192–3.
17. Aminah A, Tomayahu N, Abidin Z. Penetapan Kadar Flavonoid Total Ekstrak Etanol Kulit Buah Alpukat (Persea americana Mill.) dengan Metode Spektrofotometer UV-Vis. J Fitofarmaka Indones. 2017;4(2):226–30.
18. Mutmainah., Kusmita L, Puspitaningrum I. Pengaruh Perbedaan Konsentrasi Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L .) Terhadap Karakteristik Fisik Sediaan Gel. 2014;(2007):98–104.
19. Rowe CR, Sheskey JP, E.M. Q. Handbook of Pharmaceutical Excipients. Vol. E.28, Pharmaceutical Press and the American Pharmacists Association. 2009. 257–262 p.
20. Dewi IK, Rachmawati M, Ma’rifah FA, Susilowati P. Uji Fisik Sediaan Gel Ekstrak Tongkol Jagung (Zay Mays L). J Kebidanan dan Kesehat Tradis. 2018;3(2):70–3.
21. Naibaho OH, Yamlean PVY, Wiyono W. Pengaruh Basis Salep Terhadap Formulasi Sediaan Salep Ekstrak Daun Kemangi (Ocimum sanctum L.) Pada Kulit Punggung Kelinci yang Dibuat Infeksi Staphylococcus aureus. J Ilm Farm. 2013;2(02):27–34.
22. Tranggono R. dan FL. Buku Pegangan Ilmu Pengetahuan Kosmetik. Jakarta, Indonesia: PT. Gramedia Pusaka Umum; 2007. 21,46.
23. Forestryana D, Rahman SY. Formulasi dan Uji Stabilitas Serbuk Perasan Jeruk Nipis (Citrus aurantifolia (Cristm.) Swingle) dengan Variasi Konsentrasi Carbopol 940. JPSCR J Pharm Sci Clin Res. 2020;5(2):165.
24. Mappa T, Edy HJ, Kojong N. Formulasi Gel Ekstrak Daun Sasaladahan (Peperomia pellucida (L.) H.B.K dan Uji Efektivitasnya Terhadap Luka Bakar Pada Kelinci (Oryctolagus Cuniculus). PHARMACON J Ilm Farm – UNSRAT Vol 2 No 02 HAL 49-55. 2013;2(02):49–56.
25. Astuti DP, Husni P, Hartono K. Formulasi Dan Uji Stabilitas Fisik Sediaan Gel Antiseptik Tangan Minyak Atsiri Bunga Lavender (Lavandula angustifolia Miller). Farmaka. 2017;15(1):176–84.
26. Kumesan, Yuni Arista N., Paulina V. Y. Yamlean HSS. Formulasi Dan Uji Aktivitas Gel Antijerawat Ekstrak Umbi Bakung (Crinum Asiaticum L.) Terhadap Bakteri Staphylococcus Aureus Secara in Vitro. PHARMACON J Ilm Farm – UNSRAT. 2013;2(02):2302–493.
27. Suharyanto DANP. Penetapan Kadar Flavonoid Tota; pada Juice Daun Ubi Jalar Ungu (Ipomoea batatas L.) yang Berpotensi sebagai Hepatoprotektor dengan Metode Spektrofotometer UV-Vis. 2020;4(2):110–9.
28. Abu-hiamed HA. Research Article Chemical Composition , Flavonoids and betasitosterol Contents of Pulp and Rind of Watermelon ( Citrullus lanatus ) Fruit. Pakistan J Nutr. 2017;16((7)):502–7.
29. Ibra S, Dieng M, Diallo AJ, Dior A, Diatta-badji K, Diatta W, et al. Total polyphenols and flavonoids contents of aqueous extracts of watermelon red flesh and peels ( Citrullus lanatus , Thunb ). 2017;6(5):801–3.
30. Tobin DJ. Introduction to skin aging. J Tissue Viability. 2017;26(1):37–46.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.
This licence applies to Author(s) and Public Reader means that the users mays :
- SHARE:
copy and redistribute the article in any medium or format - ADAPT:
remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication) - ALIKE:
If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original. - NO ADDITIONAL RESTRICTIONS:
You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
It does however mean that when you use it you must:
- ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
You may not:
- NONCOMMERCIAL: You may not use the article for commercial purposes.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.