Enantiomeric ratio of sesamin in the bark of Pentaspadon motleyi (Anacardiaceae)

CHINAMI KITAMURA; PARTOMUAN SIMANJUNTAK; KAZUYOSHI KAWAZOE; SHOJI MAEHARA; KOZUYOSHI OHASHI; HIROTAKA SHIBUYA

CHINAMI KITAMURA FUKUYAMA UNIVERSITY
PARTOMUAN SIMANJUNTAK INDONESIA INSTITUTE OF SCIENCE
KAZUYOSHI KAWAZOE UNIVERSITY OF TOKUSHIMA
SHOJI MAEHARA FUKUYAMA UNIVERSITY
KOZUYOSHI OHASHI FUKUYAMA UNIVERSITY
HIROTAKA SHIBUYA FUKUYAMA UNIVERSITY

Abstract

The barks of Pentaspadon motleyi Hook. f. (Anacardiaceae) were collected from the Poso district in Central Sulawesi, Indonesia, in 1992 which it has been used traditionally as a remedy for malaria and tuberculosis in the local area. It was found that a mixture of (+)-sesamin (1) and (-)-sesamin (2) in a ratio of 100:86 were present together with lupeol in the bark of Pentaspadon motleyi. This was the first evidence of sesamin being isolated in almost equivalent amounts of (+)- and (-)-forms from a single plant species, and indicates that the biosynthetic pathway of sesamin in the plant is not enantioselective or fuzzy.

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