Efek Ekstrak Biji Leucaena leucocephala L. terhadap Profil Lipid Darah Tikus Diabetes

  • Humairoh Hanan Universitas Pancasila
  • Syamsudin Syamsudin Universitas Pancasila

Abstract

The use of Leucaena leucochepala as an antidiabetic has already been known in society, but the support experiment was very rare. The purpose of this experiment is to know whether the extract of L. leucochepala semen have an effect to the blood lipid profile of a NIDDM rat which is streptozotocin (stz) induced. It is made in 6 groups, each group consist of 5 rats. Group 1: Normal control, group 2: Negative control (stz), group 3: Positive control (clorpropamid), group 4: Extract of Leucaena semen low dose (0.25 g/kg BW), group 5: Extract of Leucaena semen medium dose (0.5 g/kg BW) and group 6: Extract Leucaena semen high dose (1 g/kg BW). Rats are made hiperglycemia with iv induction of stz 50 mg/kg BW. Chlorpropamid and Leucaena semen extract are given orally. The experiment results of blood sugar level, total cholesterol, triglyceride, HDL and LDL are analyzed by ANOVA and continued with BNT test (p < 0.05). The result from the experiment is the high reduction of blood sugar level from the Leucaena semen extract high dose in amount of 65.30%. Results from the total cholesterol level of group 1:61.60 mg/dl, group 2: 91.60 mg/dl, group 3: 62.20 mg/dl, group 4: 76.00 mg/dl, group 5: 65.40 mg/dl and group 6: 55.80 mg/dl. Results from the triglyceride level of group 1: 83.40 mg/dl, group 2: 201.40 mg/dl, group 3: 133.40 mg/dl, group 4: 114.80 mg/dl, group 5: 93.20 mg/dl and group 6: 80.40 mg/dl. Results from the HDL level of group 1: 47.60 mg/dl, group 2: 26.40 mg/dl, group 3: 35.20 mg/dl, group 4: 43.40 mg/dl, group 5:58.40 mg/dl and group 6: 90.40 mg/dl. Results from the LDL level of group 1: -2.68 mg/dl, group 2:26.72 mg/dl, group 3: 0.32 mg/dl, group 4: 9.64 mg/dl, group 5:-11.64 mg/dl and group 6: -50.16 mg/dl.

References

1. Nararto P. Penelitian pendahuluan aktivitas biologik antineoplastik ekstrak herba Dendropthoe petandra yang tumbuh pada pohon mangga. Surabaya: Fakultas Farmasi Universitas Airlangga; 1995. hal. 3.

2. Departemen Kesehatan Republik Indonesia. Penelitian tanaman obat di beberapa perguruan tinggi di Indonesia. Vol VII. Jakarta: Pusat Penelitian dan Pengembangan Farmasi; 1995. hal. 155-54.

3. Ganiswarna SG, editor. Farmakologi dan terapi. Edisi 4. Jakarta: Fakultas Kedokteran Universitas Indonesia; 1995. hal. 364 - 478.

4. Dalimartha S. Ramuan tradisional untuk pengobatan diabetes mellitus. Jakarta: Penebar Swadaya; 1999. hal. 3.

5. McEvoy GK. American hospital formulary service drug information 88. USA; hal. 1390.

6. Nurdiana, Permatasari N, Setyawati, Ali M. Efek streptozotocin sebagai bahan diabetogenik pada tikus Wistar dengan cara pemberian Intra peritoneal dan intra vena. Majalah Kedokteran Unibraw 1998;14(2):70-76.

7. Windolz M, Budavari S, Blumetti RF, Otterbein ES, editors. The Merck index an encyclopedia of chemicals, drug and biologicals. 8th ed. USA: Published by Merck & Co Inc; 1983. hal. 1266.

8. Indo Reagen. Program kerja manual indo reagen diagnostica. Jakarta: Indo Reagen; hal. 18-30.

9. Schefler WC. Statistika untuk biologi, farmasi, kedokteran dan ilmu yang bertautan. Edisi 2. Diterjemahkan oleh Suroso. Bandung: Penerbit ITB; 1987. hal. 198.

10. Pari L, Latha M. Effect of Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats. Singapore Med J. 2002;43(12):620.

11. Budijanto D, Astuti WD, Anggraeni R. Analisis kecenderungan diabetes mellitus dalam kaitannya dengan kadar kolesterol darah. Majalah Kedokteran Unibraw. 1999;15(1):3.

12. Widodo MA, Rudijanto A. Efek vitamin-E pada kadar gula darah, kolesterol LDL, HDL, trigliserida dan asam urat penderita diabetes tipe-2. Majalah Kedokteran Unibraw. 1997;13(3):132-32.
How to Cite
HANAN, Humairoh; SYAMSUDIN, Syamsudin. Efek Ekstrak Biji Leucaena leucocephala L. terhadap Profil Lipid Darah Tikus Diabetes. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 2, n. 1, p. 5-10, apr. 2004. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/637>. Date accessed: 22 dec. 2024.
Citation Formats
Issue
Vol 2 No 1 (2004): JIFI
Section
Articles

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.