Formulation of Curcuma zedoaria as an Antioxidant Emulgel

  • Yesi Desmiaty Universitas Pancasila
  • Wiwi Winarti Universitas Pancasila
  • Fahleni Fahleni Universitas Pancasila
  • Lindawati Lindawati Universitas Pancasila

Abstract

Curcuma zedoaria has a high antioxidant activity and potential to be made a topical antioxidant preparation. Emulgel is a combination of O/W emulsion with a gel base, and it has many advantages, including convenience in use. In this study, an emulgel formulation was made using Sepigel 305® with various concentrations (3%, 4%, and 5%). The emulgel formulation, the ethanol extract of C. zedoaria, was added with concentrations 1%, 2%, and 5%. The preparation was evaluated for physical quality and antioxidant activity using the DPPH method. In the selected formula, had been observing the accelerated stability tests were carried out for three months. Ethanol extract of C. zedoaria has antioxidant activity with IC50 49.72 ± 0.32 ppm. The best emulgel preparation is F2, which contains Sepigel 305® 4% and extract 2%. The F2 emulgel formulation was found to be stable physicochemical properties (organoleptic, homogeneity, viscosity, flow properties, dispersion ability, and emulsion type test) upon the accelerated stability tests, and pH met the requirements with antioxidant activity gave IC50 135.8 ppm. Ethanol extract of C. zedoaria can be made emulgel preparations using Sepigel 305®, physically and chemically stable, and has an excellent antioxidant activity for the three months of storage.

References

1. Lan TTP, Huy ND, Luong NN, Nghi N Van, Tan TH, Quan LV, et al. Identification and characterization of genes in curcuminoid pathway of Curcuma zedoaria Roscoe. Curr Pharm Biotechnol [Internet]. 2018 Oct 8 [cited 2018 Nov 19];19(10):839–46. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30295188

2. Lobo R, Prabhu KS, Shirwaikar A, Shirwaikar A. Curcuma zedoaria Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties. J Pharm Pharmacol [Internet]. 2009;61(1):13–21. Available from: http://openurl.ingenta.com/content/xref?genre=article&issn=0022-3573&volume=61&issue=1&spage=13

3. Huang SJ, Chyau CC, Tsai CH, Chen CC, Mau JL, Tsai SY. Antioxidant Properties of Extracts from Curcuma zedoaria Rhizome. Adv Mater Res [Internet]. 2015;1120–1121:920–5. Available from: http://www.scientific.net/AMR.1120-1121.920

4. Xu N, Wang L, Guan J, Tang C, He N, Zhang W, et al. Wound healing effects of a Curcuma zedoaria polysaccharide with platelet-rich plasma exosomes assembled on chitosan/silk hydrogel sponge in a diabetic rat model. Int J Biol Macromol [Internet]. 2018;117(2017):102–7. Available from: https://doi.org/10.1016/j.ijbiomac.2018.05.066

5. Jung EB, Trinh TA, Lee TK, Yamabe N, Kang KS, Song JH, et al. Curcuzedoalide contributes to the cytotoxicity of Curcuma zedoaria rhizomes against human gastric cancer AGS cells through induction of apoptosis. J Ethnopharmacol [Internet]. 2018;213:48–55. Available from: https://doi.org/10.1016/j.jep.2017.10.025

6. Singh P, Singh S, Kapoor IPS, Singh G, Isidorov V, Szczepaniak L. Chemical composition and antioxidant activities of essential oil and oleoresins from Curcuma zedoaria rhizomes, part-74. Food Biosci [Internet]. 2013;3:42–8. Available from: http://dx.doi.org/10.1016/j.fbio.2013.06.002

7. Desmiaty Y, Winarti W, Nursih AMM, Nisrina H, Finotory G. Antioxidant and antielastase activity of kaempferia rotunda and curcuma zedoaria. Res J Chem Environ. 2018;22(Special Issue 1):95–8.

8. Hadisaputri YE, Miyazaki T, Suzuki S, Kubo N, Zuhrotun A, Yokobori T, et al. Molecular characterization of antitumor effects of the rhizome extract from Curcuma zedoaria on human esophageal carcinoma cells. Int J Oncol. 2015;47(6):2255–63.

9. Rina Yanti Eff A. Efek Anti-tifoid Minyak Atsiri Temu Putih ( Curcuma zedoria Rosc .) pada Tikus ( Rattus norvegicus L ) yang Terinfeksi Salmonella typhi Anti-thypoid Effect of Essential Oil of Temu Putih ( Curcuma zedoria Rosc .) in Mouse ( Rattus norvegicus L ) Infected. Pharm Sci Res. 2018;5(3):116–22.

10. Ajazuddin, Alexander A, Khichariya A, Gupta S, Patel RJ, Giri TK, et al. Recent expansions in an emergent novel drug delivery technology: Emulgel. J Control Release [Internet]. 2013;171(2):122–32. Available from: http://dx.doi.org/10.1016/j.jconrel.2013.06.030

11. Desmiaty Y, Elya B, Saputri FC, Hanafi M, Prastiwi R. Antioxidant Activity of Rubus fraxinifolius Poir. and Rubus rosifolius J. Sm. Leaves. J Young Pharm [Internet]. 2018;10(2s):S93–6. Available from: https://www.jyoungpharm.org/article/1233

12. Elfahmi, Woerdenbag HJ, Kayser O. Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. J Herb Med. 2014;4(2):51–73.

13. Khullar R, Kumar D, Seth N, Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharm J. 2012 Jan;20(1):63–7.

14. Mohammed Haneefa KP, Easo S, Hafsa P V., Prasad Mohanta G, Nayar C. Emulgel: An advanced review. J Pharm Sci Res. 2013;5(12):254–8.

15. Bergamante V, Ceschel GC, Marazzita S. Effect of Vehicles on Topical Application of Aloe Vera and Arnica Montana Components. Drug Deliv. 2007;14(November 2006):427–32.
Published
2020-04-25
How to Cite
DESMIATY, Yesi et al. Formulation of Curcuma zedoaria as an Antioxidant Emulgel. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 18, n. 1, p. 34-40, apr. 2020. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/711>. Date accessed: 31 may 2020. doi: https://doi.org/10.35814/jifi.v18i1.711.
Section
Articles