Formulasi Curcuma zedoaria Sebagai Emulgel Antioksidan

  • Yesi Desmiaty Universitas Pancasila
  • Wiwi Winarti Universitas Pancasila
  • Fahleni Fahleni Universitas Pancasila
  • Lindawati Lindawati Universitas Pancasila
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Abstrak

Curcuma zedoaria memiliki aktivitas antioksidan yang kuat dan potensial untuk dibuat menjadi sediaan antioksidan topikal. Emulgel adalah gabungan emulsi M/A dengan basis gel, memiliki banyak keuntungan diantaranya adalah kenyamanan dalam pemakaian. Pada penelitian ini dibuat formulasi emulgel menggunakan Sepigel 305® dengan variasi konsentrasi 3%, 4%, dan 5%. Pada basis gel ditambahkan ekstrak etanol C. zedoaria dengan variasi konsentrasi 1%, 2%, dan 5%. Terhadap sediaan dilakukan evaluasi mutu fisik dan aktivitas antioksidan menggunakan metode DPPH. Pada formula terpilih dilakukan uji stabilitas dipercepat selama tiga bulan pengamatan. Ekstrak etanol C. zedoaria memiliki aktivitas antioksidan dengan IC50 49,72±0,.32 bpj. Sediaan emulgel terbaik adalah F2 yang mengandung Sepigel 305® 4% dan ekstrak 2%. Hasil uji stabilitas dipercepat menunjukkan sediaan stabil secara fisik (organoleptik, homogenitas, viskositas, sifat alir, kemampuan menyebar, dan uji tipe emulsi), pH memenuhi syarat dengan IC50 135.8 bpj. Ekstrak etanol  C. zedoaria dapat dibuat sediaan emulgel dengan menggunakan Sepigel 305®, stabil secara fisik dan kimia serta memiliki aktivitas antioksidan yang baik selama tiga bulan penyimpanan.

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Diterbitkan
2020-04-25
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DESMIATY, Yesi et al. Formulasi Curcuma zedoaria Sebagai Emulgel Antioksidan. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 18, n. 1, p. 34-40, apr. 2020. ISSN 2614-6495. Tersedia pada: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/711>. Tanggal Akses: 03 sep. 2025 doi: https://doi.org/10.35814/jifi.v18i1.711.
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