Comparison of Side Effects Propofol-Fentanyl and Propofol-Fentanyl-Midazolam in Central Medical Installation Hospital X Bogor

  • Silvi Nurafni Sekolah tinggi teknologi industri dan farmasi bogor
  • Tri Desminingrum RSUD ciawi
  • Evida Mainanda


Propofol is one of the most commonly used intravenous drugs employed to induce and maintain general anesthesia. The effective induction dose of propofol is 1.0-2.5 mg/kg IV caused hemodynamic instability significant as hypotension. Stability hemodynamic in used propofol can optimized with midazolam-fentanyl. The aims of this study was to determine the comparison of side effects propofol-fentanyl and propofol-fentanyl-midazolam in patient undergoing elective surgery with parameter of blood pressure, pulse, respiratory rate (RR). This study was a observational with prospective method in 60 patients undergoing elective surgery with physical status ASA I-II conducted  in the period of April to July 2019. The result showed the induction anesthesia used of propofol-fentanyl caused decreased on systolic blood pressure 17,2±3 mmHg, diastolic blood pressure 5,3±1,6 mmHg, pulse 3,9±1,5 beats/minute, and RR 1,4±0,01 breaths/minute. The induction anesthesia used of propofol-fentanyl-midazolam caused decreased on systolic blood pressure 11,8±0,4 mmHg, diastolic blood preasure 4,2±0,4 mmHg, pulse value 5,0±0,9 beats/minute, and RR 2,8±0,9 breaths/minute. Side effects in the form of blood pressure, pulse and respiratory rate from the administration of the combination of propofol-fentanyl and propofol-fentanyl-midazolam were not significantly different.


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How to Cite
NURAFNI, Silvi; DESMININGRUM, Tri; MAINANDA, Evida. Comparison of Side Effects Propofol-Fentanyl and Propofol-Fentanyl-Midazolam in Central Medical Installation Hospital X Bogor. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 20, n. 1, p. 1-5, apr. 2022. ISSN 2614-6495. Available at: <>. Date accessed: 17 apr. 2024. doi: