Comparison of Side Effects Propofol-Fentanyl and Propofol-Fentanyl-Midazolam in Central Medical Installation Hospital X Bogor

  • Silvi Nurafni Sekolah tinggi teknologi industri dan farmasi bogor
  • Tri Desminingrum RSUD ciawi
  • Evida Mainanda

Abstract

Propofol is one of the most commonly used intravenous drugs employed to induce and maintain general anesthesia. The effective induction dose of propofol is 1.0-2.5 mg/kg IV caused hemodynamic instability significant as hypotension. Stability hemodynamic in used propofol can optimized with midazolam-fentanyl. The aims of this study was to determine the comparison of side effects propofol-fentanyl and propofol-fentanyl-midazolam in patient undergoing elective surgery with parameter of blood pressure, pulse, respiratory rate (RR). This study was a observational with prospective method in 60 patients undergoing elective surgery with physical status ASA I-II conducted  in the period of April to July 2019. The result showed the induction anesthesia used of propofol-fentanyl caused decreased on systolic blood pressure 17,2±3 mmHg, diastolic blood pressure 5,3±1,6 mmHg, pulse 3,9±1,5 beats/minute, and RR 1,4±0,01 breaths/minute. The induction anesthesia used of propofol-fentanyl-midazolam caused decreased on systolic blood pressure 11,8±0,4 mmHg, diastolic blood preasure 4,2±0,4 mmHg, pulse value 5,0±0,9 beats/minute, and RR 2,8±0,9 breaths/minute. Side effects in the form of blood pressure, pulse and respiratory rate from the administration of the combination of propofol-fentanyl and propofol-fentanyl-midazolam were not significantly different.

References

1. Chang CC, Wong CS. Postoperative nausea and vomiting free for all: A solution from propofol? Acta Anaesthesiologica Taiwanica. 2016.

2. Inayati IDKZI. Evaluasi efektivitas dan keamanan penggunaan obat anestesi umum di RS PKU Muhammadiyah Yogyakarta. Farmasains J Farm dan Ilmu Kesehat. 2012.

3. das Neves JFNP, das Neves Araújo MMP, de Paiva Araújo F, Ferreira CM, Duarte FBN, Pace FH, et al. Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam. Brazilian J Anesthesiol. 2016.

4. Latmore M, Litwin S, Kwofie K, Shastri U, Vandepitte C, Kuroda M, et al. Sedation during surgery under regional anesthesia: which drug is best for my patient? Reg Anesth Pain Med. 2012.

5. Ghatak, T., Singh, D., Kapoor, R., Bogra, J., 2012. Effects of addition of ketamine, fentanyl and saline with propofol induction on hemodynamics and laryngeal mask airway insertion conditions in oral clonidine premedicated children. Saudi J Anaesth, 6(2), 140-144.

6. Tobias JD, Leder M. Procedural sedation: A review of sedative agents, monitoring, and management of complications. Saudi Journal of Anaesthesia. 2011.

7. Gangka Y, Kadir A, Semana A. Faktor yang berhubungan dengan tingkat kecemasan pasien pre operasi bedah mayor digestif di RSUP Dr Wahidin Sudirohusodo Makassar. J Ilm Kesehat Diagnosis. 2013.

8. Reves JG, Fragen RJ, Vinik HR, Greenblatt DJ. Midazolam: pharmacology and uses. Anesthesiology. 1985.

9. Short TG, Chui PT. Propofol and midazolam act synergistically in combination. Br J Anaesth. 1991;
Published
2022-04-21
How to Cite
NURAFNI, Silvi; DESMININGRUM, Tri; MAINANDA, Evida. Comparison of Side Effects Propofol-Fentanyl and Propofol-Fentanyl-Midazolam in Central Medical Installation Hospital X Bogor. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 20, n. 1, p. 1-5, apr. 2022. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/817>. Date accessed: 02 july 2022. doi: https://doi.org/10.35814/jifi.v20i1.817.
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Articles