Curcuminoids Content and α-Glucosidase Inhibition of ExtractPromising Lines of Curcuma xanthorrhiza RoxB.

  • WARAS NURCHOLIS INSTITUT PERTANIAN BOGOR
  • LAKSMI AMBARSARI INSTITUT PERTANIAN BOGOR
  • GIA PERMASKU INSTITUT PERTANIAN BOGOR
  • LATIFAH k DARUSMAN INSTITUT PERTANIAN BOGOR
  • POPI ASRI KURNIATIN INSTITUT PERTANIAN BOGOR

Abstrak

Curcuma xanthorrhiza Roxb.is one type of Indonesian herbs derived from family
Zingiberaceae. Curcuminoids is generally considered it’s most active constituent on C. xanthorrhiza
that response biological activities. Present study evaluates the curcuminoids content and α-glucosidase
inhibition of the four extracts of promoting lines of C. xanthorrhiza from West Java (Sukabumi), Central
Java (Wonogiri and Karanganyar), East Java (Ngawi) and one extract varieties of C. xanthorrhiza from Bogor-West Java. For that purpose, dry-powdered of C.xanthorrhiza were sequentially extracted with ethanol and n-hexane. HPLC method was used to determine curcuminoids content. The α-glucosidase inhibitory effect of extracts C.xanthorrhiza was measured in vitro with microplate reader at 410 nm. The highest curcuminoids content were found to be in the promoting lines of C. xanthorrhiza from Wonogiri, which ranged from 35,57 ̵ 85,19 mg/g. IC50 values for α-glucosidase inhibitor activity ranged from 333,27 ̵ 908,35 μg/mL, with the promoting lines of C. xanthorrhiza from Wonogiri having the lowest value and therefore the most potent. In this study, the promoting lines of C.xanthorrhiza from Wonogiri exhibited most in curcuminoids content and α-glucosidase inhibitory than promoting lines from Sukabumi, Karanganyar, Ngawi, and varieties from Bogor.

Diterbitkan
2017-09-23
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NURCHOLIS, WARAS et al. Curcuminoids Content and α-Glucosidase Inhibition of ExtractPromising Lines of Curcuma xanthorrhiza RoxB.. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 13, n. 2, p. 229-234, sep. 2017. ISSN 2614-6495. Tersedia pada: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/98>. Tanggal Akses: 31 mar. 2025
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Vol 13 No 2 (2015): JIFI
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